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Presented by OrthoEvidence |
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ACE REPORTS |
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PRP has been increasingly offered despite high cost, limited AAOS endorsement, and lack of FDA approval; moreover, few rigorous RCTs directly compare PRP with CS—an effective, cost-efficient option with benefits lasting up to ~3 months. This trial addresses the short-term comparative effectiveness gap to inform expectations and value-based decision-making.
53 patients with symptomatic knee osteoarthritis were randomized to receive either platelet-rich plasma (PRP) or corticosteroid injection with triamcinolone acetonide. The primary outcome of interest was pain, measured on a Visual Analog Scale (VAS). Secondary outcomes included knee-specific and functional outcomes.
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At 6 weeks, patients who received corticosteroid reported significantly greater reductions in pain compared to the PRP group. Clinically relevant improvements were observed in the corticosteroid group but not the PRP group.
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At 3 months, both groups reported similar levels of pain improvement.
Bottom line. Corticosteroid appears to provide significantly greater pain reduction at 6 weeks post-injection compared to PRP. This study suggests that expectations regarding the clinical utility of PRP should be tempered.
Read the full ACE Report on this study here.
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OE ORIGINALS |
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As the use of Ozempic expands, evidence on their potential effects on the musculoskeletal system has been coming to light. For the orthopaedic surgeon, understanding the pros and cons of GLP-1 usage in patients is essential.
In this OE Original, we explore the current scientific literature on how GLP-1 RAs influence osteoarthritis, bone health, fracture risk and orthopedic surgery outcomes.
Read the full article here.
Sourced from ESPN. |
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OE PODCASTS |
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In this OrthoPod, we sat down with Dr. Jans van der Merwe, an orthopaedic surgeon from Saskatchewan specializing in hip and knee replacement, for a discussion on his pathway to orthopaedics, the responsiveness of the Canadian medical system to new innovations in the field, and controversial topics in arthroplasty (including implant types, patellar resurfacing, and more!).
Watch the full podcast here.
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MOST READ ORTHOPAEDIC RESEARCH IN 2025 |
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Does FHL Tendon Transfer Alter the Outcome of Haglund Deformity Treatment in Patients Older Than 50 – In patients older than 50 years with chronic Achilles tendinopathy due to Haglund deformity, does flexor hallucis longus tendon transfer in addition to debridement and ostectomy, improve clinical outcomes compared to debridement and ostectomy alone, over one year? (Read)
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Initial Surgery vs Corticosteroid Injection for Carpal Tunnel Syndrome – In adults with confirmed carpal tunnel syndrome, does initial surgical carpal tunnel release result in a higher proportion of recovery when compared with corticosteroid injection over 18 months? (Read)
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Total Hip Replacement vs. Resistance Training for Severe Hip Osteoarthritis in older adults – In patients aged 50 years or older with severe hip osteoarthritis, does total hip replacement affect patient-reported hip pain and function compared to resistance training over a 6-month period? (Read)
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Manipulation Under Anesthesia to Treat Postoperative Stiffness After Total Knee Arthroplasty – In patients who develop postoperative stiffness after total knee arthroplasty, does the addition of intravenous dexamethasone and oral celecoxib to manipulation under anesthesia (MUA) and physical therapy (PT) improve range of motion (ROM) and clinical outcomes compared to MUA and PT alone over one year? (Read)
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Effectiveness of Reducing Tendon Compression in Rehabilitation of Insertional Achilles Tendinopathy – In sport-active adults with chronic insertional Achilles tendinopathy, does a low tendon compression rehabilitation program result in greater improvement in pain and function when compared with a high tendon compression rehabilitation program over 24 weeks? (Read)
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Comparing Arthroscopic Surgery to Conservative Treatment in Knee Osteoarthritis – In patients with knee osteoarthritis, does arthroscopic surgery result in improved pain relief, functional recovery, and patient satisfaction compared to conservative treatments over a long-term follow-up? (Read)
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Micro-Fragmented Adipose Tissue vs Saline for Knee Osteoarthritis – In adults with symptomatic tibiofemoral knee osteoarthritis, does a single intra-articular injection of autologous micro-fragmented adipose tissue result in greater improvement in KOOS4 when compared with a single intra-articular saline injection over 24 months? (Read)
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